MK6-83
Modify Date: 2024-01-09 17:39:18
MK6-83 structure
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Common Name | MK6-83 | ||
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| CAS Number | 1062271-24-2 | Molecular Weight | 336.472 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 502.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C16H20N2O2S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 257.8±32.9 °C | |
Use of MK6-83MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1]. |
| Name | 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide |
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| Synonym | More Synonyms |
| Description | MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1]. |
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| Related Catalog | |
| In Vitro | MK6-83 2 ranging from 0.2 to 30 μM shows no signs of cytotoxicity[1]. MK6-83 appears to be significantly more efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells than on those isolated from TRPML1-/- cells[1]. Cell Viability Assay[1]. Cell Line: Lysosomes isolated from fibroblast cell lines derived from MLIV patients carrying either the F408D, the R403C or the V446L mutation[1]. Concentration: 0-10 μM. Incubation Time: 24 h. Result: Efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells. Had no significant effect on lysosomes isolated from TRPML1-/- fibroblasts. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 502.6±60.0 °C at 760 mmHg |
| Molecular Formula | C16H20N2O2S2 |
| Molecular Weight | 336.472 |
| Flash Point | 257.8±32.9 °C |
| Exact Mass | 336.096619 |
| LogP | 3.40 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.633 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
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| 2-Thiophenesulfonamide, 5-methyl-N-[2-(1-piperidinyl)phenyl]- |
| 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide |