1062271-24-2
1062271-24-2 structure
- Name: MK6-83
- Chemical Name: 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
- CAS Number: 1062271-24-2
- Molecular Formula: C16H20N2O2S2
- Molecular Weight: 336.472
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2018-06-03 17:56:27
- Modify Date: 2024-01-09 17:39:18
-
MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1].
| Name | 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide |
|---|---|
| Synonyms |
2-Thiophenesulfonamide, 5-methyl-N-[2-(1-piperidinyl)phenyl]-
5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide |
| Description | MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1]. |
|---|---|
| Related Catalog | |
| In Vitro | MK6-83 2 ranging from 0.2 to 30 μM shows no signs of cytotoxicity[1]. MK6-83 appears to be significantly more efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells than on those isolated from TRPML1-/- cells[1]. Cell Viability Assay[1]. Cell Line: Lysosomes isolated from fibroblast cell lines derived from MLIV patients carrying either the F408D, the R403C or the V446L mutation[1]. Concentration: 0-10 μM. Incubation Time: 24 h. Result: Efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells. Had no significant effect on lysosomes isolated from TRPML1-/- fibroblasts. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 502.6±60.0 °C at 760 mmHg |
| Molecular Formula | C16H20N2O2S2 |
| Molecular Weight | 336.472 |
| Flash Point | 257.8±32.9 °C |
| Exact Mass | 336.096619 |
| LogP | 3.40 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.633 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
|---|