Ms-PEG6-Ms

Modify Date: 2024-01-09 22:52:30

Ms-PEG6-Ms Structure
Ms-PEG6-Ms structure
Common Name Ms-PEG6-Ms
CAS Number 109789-40-4 Molecular Weight 474.54200
Density N/A Boiling Point N/A
Molecular Formula C14H34O13S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ms-PEG6-Ms


Ms-PEG6-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol,methanesulfonic acid
Synonym More Synonyms

 Ms-PEG6-Ms Biological Activity

Description Ms-PEG6-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C14H34O13S2
Molecular Weight 474.54200
Exact Mass 474.14400
PSA 212.11000
LogP 0.22360

 Synthetic Route

~99%

Ms-PEG6-Ms Structure

Ms-PEG6-Ms

CAS#:109789-40-4

Literature: Guenet, Aurelie; Ernest Graf; Nathalie Kyritsakas; Hosseini, Mir Wais Inorganic Chemistry, 2010 , vol. 49, # 4 p. 1872 - 1883

~25%

Ms-PEG6-Ms Structure

Ms-PEG6-Ms

CAS#:109789-40-4

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503

 Synonyms

3,6,9,12,15-Pentaoxaheptadecane-1,17-diol,dimethanesulfonate
hexaethylene glycol bis(methanesulfonate)
PEG6-di-OMs
methanesulfonic acid 2-[2-(2-{2-[2-(2-methanesulfonyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl ester
hexaethylene glycol bismesylate
hexaethylene glycol dimesylate
hexaethylene glycol dimethanesulfonate
Ms-PEG6-Ms