Sch 37370

Modify Date: 2024-01-08 21:40:59

Sch 37370 Structure
Sch 37370 structure
 Common Name Sch 37370
CAS Number 117796-52-8 Molecular Weight 352.85700
Density 1.257g/cm3 Boiling Point 546.9ºC at 760mmHg
Molecular Formula C21H21ClN2O Melting Point N/A
MSDS N/A Flash Point 284.5ºC

 Use of Sch 37370


N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1].

 Names

Name 1-[4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]ethanone
Synonym More Synonyms

 Sch 37370 Biological Activity

Description N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1].
Related Catalog
References

[1]. Billah MM, et, al. Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids. 1991 Dec;26(12):1172-4.  

 Chemical & Physical Properties

Density 1.257g/cm3
Boiling Point 546.9ºC at 760mmHg
Molecular Formula C21H21ClN2O
Molecular Weight 352.85700
Flash Point 284.5ºC
Exact Mass 352.13400
PSA 33.20000
LogP 4.21570
Vapour Pressure 5.15E-12mmHg at 25°C
Index of Refraction 1.626
Storage condition -20°C

 Synthetic Route

Desloratadine structure

Desloratadine

CAS#:100643-71-8

Acetyl chloride structure

Acetyl chloride

CAS#:75-36-5

~%

Sch 37370 Structure

Sch 37370

CAS#:117796-52-8

Literature: Mu, Shuai; Xie, Xiao-Shuai; Niu, Duan; Zhang, Da-Shuai; Liu, Deng-Ke; Liu, Chang-Xiao Chinese Chemical Letters, 2013 , vol. 24, # 6 p. 531 - 534
Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7

Desloratadine structure

Desloratadine

CAS#:100643-71-8

~81%

Sch 37370 Structure

Sch 37370

CAS#:117796-52-8

Literature: Mezei, Tibor; Volk, Balazs; Kiraly, Imre; Simig, Gyula Organic Process Research and Development, 2008 , vol. 12, # 5 p. 855 - 859
N-tert-butyl-3-methylpyridine-2-carboxamide structure

N-tert-butyl-3-...

CAS#:32998-95-1

~%

Sch 37370 Structure

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
Loratadine Impurity 18 structure

Loratadine Impu...

CAS#:31255-57-9

~%

Sch 37370 Structure

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
3-[2-(3-CHLORO-PHENYL)-ETHYL]-PYRIDINE-2-CARBOXYLIC ACID TERT-BUTYLAMIDE structure

3-[2-(3-CHLORO-...

CAS#:107285-30-3

~%

Sch 37370 Structure

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
(1-Methyl-4-piperidinyl) {3[2-(3-chlorophenyl) ethyl ]2-pyridinyl} methanone structure

(1-Methyl-4-pip...

CAS#:130642-50-1

~%

Sch 37370 Structure

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
Loratadine structure

Loratadine

CAS#:79794-75-5

~%

Sch 37370 Structure

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
m-Chlorbenzyl chloride structure

m-Chlorbenzyl c...

CAS#:620-20-2

~%

Sch 37370 Structure

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
N-Methyl Desloratadine structure

N-Methyl Deslor...

CAS#:38092-89-6

~%

Sch 37370 Structure

Sch 37370

CAS#:117796-52-8

Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

 Synonyms

N-Acetyldesloratadine
PegCNTF
RESPATADINE
Loratadine Impurity 11
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Chemsrc provides Sch 37370(CAS#:117796-52-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Sch 37370 are included as well.>> amp version: Sch 37370

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