hydroxychloroquine

Modify Date: 2024-01-02 11:10:24

hydroxychloroquine Structure
hydroxychloroquine structure
Common Name hydroxychloroquine
CAS Number 118-42-3 Molecular Weight 335.87200
Density 1.176 g/cm3 Boiling Point 516.7ºC at 760 mmHg
Molecular Formula C18H26ClN3O Melting Point 89-91°
MSDS N/A Flash Point 266.3ºC

 Use of hydroxychloroquine


Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

 Names

Name hydroxychloroquine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.176 g/cm3
Boiling Point 516.7ºC at 760 mmHg
Melting Point 89-91°
Molecular Formula C18H26ClN3O
Molecular Weight 335.87200
Flash Point 266.3ºC
Exact Mass 335.17600
PSA 48.39000
LogP 3.85600
Vapour Pressure 1.68E-11mmHg at 25°C
Index of Refraction 1.5790 (estimate)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KK3325000
CHEMICAL NAME :
Ethanol, 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-
CAS REGISTRY NUMBER :
118-42-3
BEILSTEIN REFERENCE NO. :
0253894
LAST UPDATED :
199703
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C18-H26-Cl-N3-O
MOLECULAR WEIGHT :
335.92
WISWESSER LINE NOTATION :
T66 BNJ EMY1&3N2&2Q IG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Brain and Coverings - increased intracranial pressure Behavioral - convulsions or effect on seizure threshold Cardiac - other changes
REFERENCE :
JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 14,186,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
88 mg/kg/11D-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- Volume(issue)/page/year: 12,857,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
112 mg/kg/2W-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, irritative (after systemic exposure)
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 12,391,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
429 mg/kg/25D
TOXIC EFFECTS :
Blood - agranulocytosis Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,1275,1965
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
154 mg/kg/18D-I
TOXIC EFFECTS :
Behavioral - toxic psychosis
REFERENCE :
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- Volume(issue)/page/year: 12,863,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 12,184,1969

 Safety Information

Hazard Codes Xn
Risk Phrases R22;R36
Safety Phrases S26
HS Code 3004390090

 Synthetic Route

~%

hydroxychloroquine Structure

hydroxychloroquine

CAS#:118-42-3

Literature: DE838142 , ; DRP/DRBP Org.Chem. US2546658 , ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
EINECS 204-249-8
MFCD00078203
Oxichlorochinum
Plaquenil
Oxichloroquine
Polirreumin
Hydroxychlorochin
Oxychlorochin
Hidroxicloroquina
Quensyl
Oxychloroquine
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