Desethyl Hydroxychloroquine-d4

Modify Date: 2024-01-10 13:23:27

Desethyl Hydroxychloroquine-d4 structure	Common Name	Desethyl Hydroxychloroquine-d4
	CAS Number	1854126-47-8	Molecular Weight	311.84
	Density	1.2±0.1 g/cm3	Boiling Point	514.7±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₈D₄ClN₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	265.1±30.1 °C

Use of Desethyl Hydroxychloroquine-d4

Cletoquine-d4 is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

Name	Desethyl Hydroxychloroquine-d4
Synonym	More Synonyms

Description	Cletoquine-d4 is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Research Areas >> Inflammation/Immunology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kumar M, et al. Molecular docking studies of chloroquine and its derivatives against P23pro-zbd domain of chikungunya virus: Implication in designing of novel therapeutic strategies. J Cell Biochem. 2019 Oct;120(10):18298-18308. [3]. Charlier B, et al. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood. Biomed Chromatogr. 2018 Aug;32(8):e4258. [4]. Chhonker YS, et al. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC-ESI-MS/MS: An application for pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:320-327.

Density	1.2±0.1 g/cm3
Boiling Point	514.7±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₈D₄ClN₃O
Molecular Weight	311.84
Flash Point	265.1±30.1 °C
Exact Mass	311.170258
LogP	2.60
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.623

Desethyl Hydroxychloroquine-d4

2-({4-[(7-Chloro-4-quinolinyl)amino]pentyl}amino)(2H4)ethanol

Ethan-1,1,2,2-d4-ol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]amino]-

Desethyl Hydroxychloroquine-d4

Use of Desethyl Hydroxychloroquine-d4

Names

Desethyl Hydroxychloroquine-d4 Biological Activity

Chemical & Physical Properties

Synonyms