FLUTRIMAZOLE

Modify Date: 2024-01-10 10:20:12

FLUTRIMAZOLE Structure
FLUTRIMAZOLE structure
 Common Name FLUTRIMAZOLE
CAS Number 119006-77-8 Molecular Weight 346.373
Density 1.2±0.1 g/cm3 Boiling Point 457.1±40.0 °C at 760 mmHg
Molecular Formula C22H16F2N2 Melting Point 161-166ºC
MSDS N/A Flash Point 230.3±27.3 °C

 Use of FLUTRIMAZOLE


Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component[1].

 Names

Name flutrimazole
Synonym More Synonyms

 FLUTRIMAZOLE Biological Activity

Description Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component[1].
Related Catalog
References

[1]. Merlos M, et al. Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent. Inflamm Res. 1996;45(1):20-25.

[2]. Ramis J, et al. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997;47(10):1139-1144.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 457.1±40.0 °C at 760 mmHg
Melting Point 161-166ºC
Molecular Formula C22H16F2N2
Molecular Weight 346.373
Flash Point 230.3±27.3 °C
Exact Mass 346.128143
PSA 17.82000
LogP 4.95
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.590

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI6259450
CHEMICAL NAME :
1H-Imidazole, 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-
CAS REGISTRY NUMBER :
119006-77-8
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C22-H16-F2-N2
MOLECULAR WEIGHT :
346.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
808 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1079 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

 Articles20

More Articles
Double-blind randomized dose-finding study in acute vulvovaginal candidosis. Comparison of flutrimazole site-release cream (1, 2 and 4%) with placebo site-release vaginal cream.

Mycoses 43(9-10) , 355-65, (2000)

A double-blind randomized comparative phase II study of flutrimazole site-release vaginal cream (1, 2 and 4%) with placebo site-release vaginal cream was undertaken in patients with acute vulvovaginal...

Efficacy of flutrimazole 1% powder in the treatment of tinea pedis.

Mycoses 46(3-4) , 126-31, (2003)

The aim of the study was to compare the efficacy and tolerability of flutrimazole 1% powder vs. bifonazole 1% powder in treating tinea pedis. A multicentre, double blind, randomized, parallel and comp...

Study to compare the efficacy and safety of fluconazole cream with flutrimazole cream in the treatment of superficial mycosis: a multicentre, randomised, double-blind, phase III trial.

Mycoses 53(6) , 522-9, (2010)

Fluconazole, which is a drug of the azole family, is safely used in systemic treatment of oral and intravenous injection, but it is difficult to use fluconazole as a topical application because of its...

 Synonyms

Flutrimazolum
1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-Imidazol
Flutrimazole (INN)
FLUTRIMAZOLE
1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole
Micetal
Flutrimazolum [INN-Latin]
Flutrimazol [INN-Spanish]
1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
MFCD00865591
Flutrimazol
1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
1-[o-Fluoro-a-(p-fluorophenyl)-a-phenylbenzyl]imidazole
1H-Imidazole, 1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-
UR-4056
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