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119006-77-8

119006-77-8 structure
119006-77-8 structure
  • Name: FLUTRIMAZOLE
  • Chemical Name: flutrimazole
  • CAS Number: 119006-77-8
  • Molecular Formula: C22H16F2N2
  • Molecular Weight: 346.373
  • Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
  • Create Date: 2018-09-14 06:16:00
  • Modify Date: 2024-01-10 10:20:12
  • Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component[1].
Name flutrimazole
Synonyms Flutrimazolum
1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-Imidazol
Flutrimazole (INN)
FLUTRIMAZOLE
1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole
Micetal
Flutrimazolum [INN-Latin]
Flutrimazol [INN-Spanish]
1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
MFCD00865591
Flutrimazol
1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
1-[o-Fluoro-a-(p-fluorophenyl)-a-phenylbenzyl]imidazole
1H-Imidazole, 1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-
UR-4056
Description Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component[1].
Related Catalog
References

[1]. Merlos M, et al. Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent. Inflamm Res. 1996;45(1):20-25.

[2]. Ramis J, et al. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997;47(10):1139-1144.
Density 1.2±0.1 g/cm3
Boiling Point 457.1±40.0 °C at 760 mmHg
Melting Point 161-166ºC
Molecular Formula C22H16F2N2
Molecular Weight 346.373
Flash Point 230.3±27.3 °C
Exact Mass 346.128143
PSA 17.82000
LogP 4.95
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.590

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI6259450
CHEMICAL NAME :
1H-Imidazole, 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-
CAS REGISTRY NUMBER :
119006-77-8
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C22-H16-F2-N2
MOLECULAR WEIGHT :
346.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
808 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1079 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

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