EB 47, PARP-1 inhibitor
Modify Date: 2024-01-06 13:40:57
EB 47, PARP-1 inhibitor structure
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Common Name | EB 47, PARP-1 inhibitor | ||
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| CAS Number | 1190332-25-2 | Molecular Weight | 610.450 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H29Cl2N9O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EB 47, PARP-1 inhibitorEB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite[1]. |
| Name | 2-(4-{[(2R,3R,4S,5S)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]carbonyl}-1-piperazinyl)-N-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)acetamide dihydrochloride |
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| Synonym | More Synonyms |
| Description | EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite[1]. |
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| Related Catalog | |
| In Vitro | EB-47 dihydrochloride shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC50 values of 0.86 and 1.0 µM, respectively[1]. |
| In Vivo | EB-47 dihydrochloride (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation[3]. |
| References |
| Molecular Formula | C24H29Cl2N9O6 |
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| Molecular Weight | 610.450 |
| Exact Mass | 609.161804 |
| 2-(4-{[(2R,3R,4S,5S)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]carbonyl}-1-piperazinyl)-N-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)acetamide dihydrochloride |