Fatostatin A
Modify Date: 2024-01-30 20:50:37
Fatostatin A structure
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Common Name | Fatostatin A | ||
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| CAS Number | 125256-00-0 | Molecular Weight | 294.41400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H18N2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Fatostatin AFatostatin A is a inhibitor of SREBP that directly binds SCAP and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cellstarget: SREBPIC50: 2.5 ~10 μMIn vitro: Fatostatin A suppress cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. [1] Fatostatin potently inhibited cell growth.[2]In vivo: Fatostatin A cause G2/M cell cycle arrest and induce apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP. [1] μCT analyses show that fatostatin A treatment preserve bone mass and structure in the proximal tibial trabecular bone in the mouse RANKL-induced bone loss model.[3] |
| Name | 4-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-2-propylpyridine |
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| Synonym | More Synonyms |
| Description | Fatostatin A is a inhibitor of SREBP that directly binds SCAP and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cellstarget: SREBPIC50: 2.5 ~10 μMIn vitro: Fatostatin A suppress cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. [1] Fatostatin potently inhibited cell growth.[2]In vivo: Fatostatin A cause G2/M cell cycle arrest and induce apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP. [1] μCT analyses show that fatostatin A treatment preserve bone mass and structure in the proximal tibial trabecular bone in the mouse RANKL-induced bone loss model.[3] |
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| Related Catalog | |
| References |
| Molecular Formula | C18H18N2S |
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| Molecular Weight | 294.41400 |
| Exact Mass | 294.11900 |
| PSA | 54.02000 |
| LogP | 5.13300 |
| Storage condition | 2-8℃ |
| HS Code | 2934100090 |
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| HS Code | 2934100090 |
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| Summary | 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
| Hexatype Brown N |
| Typogen Brown N |
| Resinol RRN |
| Solvent Brown 1 |
| fatostatin A |
| Sudan Brown YR |
| Sudan Brown RR |
| Fat Brown RR |
| 1-naphthylamin->m-phenylendiamin |
| C.I. Solvent Brown 1 |
| 4-naphthalen-1-yl-diazenyl-benzene-1,3-diamine |
| Lithofor Brown A |