DHODH-IN-12
Modify Date: 2024-01-10 21:20:35
DHODH-IN-12 structure
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Common Name | DHODH-IN-12 | ||
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| CAS Number | 1263303-93-0 | Molecular Weight | 203.20 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H9N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DHODH-IN-12DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07[1]. |
| Name | DHODH-IN-12 |
|---|
| Description | DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07[1]. |
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| Related Catalog | |
| Target |
pKa: 5.07 (DHODH)[1] |
| In Vitro | Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1]. |
| References |
| Molecular Formula | C10H9N3O2 |
|---|---|
| Molecular Weight | 203.20 |