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1263303-93-0

1263303-93-0 structure
1263303-93-0 structure
  • Name: DHODH-IN-12
  • Chemical Name: DHODH-IN-12
  • CAS Number: 1263303-93-0
  • Molecular Formula: C10H9N3O2
  • Molecular Weight: 203.20
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
  • Create Date: 2020-04-08 19:21:39
  • Modify Date: 2024-01-10 21:20:35
  • DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07[1].

Name DHODH-IN-12
Description DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07[1].
Related Catalog
Target

pKa: 5.07 (DHODH)[1]

In Vitro Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].
References

[1]. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.

Molecular Formula C10H9N3O2
Molecular Weight 203.20