Name | DHODH-IN-12 |
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Description | DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07[1]. |
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Related Catalog | |
Target |
pKa: 5.07 (DHODH)[1] |
In Vitro | Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1]. |
References |
Molecular Formula | C10H9N3O2 |
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Molecular Weight | 203.20 |