Bis-PEG9-acid

Modify Date: 2024-01-04 13:02:42

Bis-PEG9-acid Structure
Bis-PEG9-acid structure
Common Name Bis-PEG9-acid
CAS Number 1268488-70-5 Molecular Weight 514.561
Density 1.2±0.1 g/cm3 Boiling Point 630.0±55.0 °C at 760 mmHg
Molecular Formula C22H42O13 Melting Point N/A
MSDS N/A Flash Point 201.6±25.0 °C

 Use of Bis-PEG9-acid


Bis-​PEG9-​acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-​PEG9-​acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name Bis-PEG10-acid
Synonym More Synonyms

 Bis-PEG9-acid Biological Activity

Description Bis-​PEG9-​acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-​PEG9-​acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

PEGs

Cleavable

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References

[1]. Bach A, et al. Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDAreceptor interaction. Angew Chem Int Ed Engl. 2009;48(51):9685-9.

[2]. Norbert Basler, et al. Nucleoside-triphosphate conjugate and methods for the use thereof. WO2012150035A1.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 630.0±55.0 °C at 760 mmHg
Molecular Formula C22H42O13
Molecular Weight 514.561
Flash Point 201.6±25.0 °C
Exact Mass 514.262512
LogP -3.33
Vapour Pressure 0.0±4.0 mmHg at 25°C
Index of Refraction 1.472
Storage condition 2-8°C

 Synonyms

HOOCCH2CH2-PEG24-CH2CH2COOH
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