1268488-70-5

1268488-70-5 structure

Name: Bis-PEG9-acid
Chemical Name: Bis-PEG10-acid
CAS Number: 1268488-70-5
Molecular Formula: C₂₂H₄₂O₁₃
Molecular Weight: 514.561
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-06-12 01:22:19
Modify Date: 2024-01-04 13:02:42
Bis-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	Bis-PEG10-acid
Synonyms	HOOCCH2CH2-PEG24-CH2CH2COOH

Description	Bis-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Bach A, et al. Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDAreceptor interaction. Angew Chem Int Ed Engl. 2009;48(51):9685-9. [2]. Norbert Basler, et al. Nucleoside-triphosphate conjugate and methods for the use thereof. WO2012150035A1.