(-)-JQ-1

Modify Date: 2024-01-21 15:03:00

(-)-JQ-1 structure	Common Name	(-)-JQ-1
	CAS Number	1268524-71-5	Molecular Weight	456.988
	Density	1.3±0.1 g/cm3	Boiling Point	610.4±65.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₅ClN₄O₂S	Melting Point	N/A
	MSDS	USA	Flash Point	322.9±34.3 °C

Use of (-)-JQ-1

(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.

Name	()-jq1
Synonym	More Synonyms

Description	(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.
Related Catalog	Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain Research Areas >> Cancer
Target	BET bromodomain[1]
In Vitro	(−)-JQ1 shows no significant interaction with any bromodomain. Besides, (−)-JQ1 enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC)[1].
References	[1]. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73. [2]. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.

Density	1.3±0.1 g/cm3
Boiling Point	610.4±65.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₅ClN₄O₂S
Molecular Weight	456.988
Flash Point	322.9±34.3 °C
Exact Mass	456.138672
PSA	97.61000
LogP	4.49
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.657
Storage condition	-20°C

RIDADR	NONH for all modes of transport

Targeting bromodomains: epigenetic readers of lysine acetylation.

Nat. Rev. Drug Discov. 13(5) , 337-56, (2014)

Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant acetylation levels have been linked to the development of several diseases. Acetyl-lysine modifications create dockin...

Epigenetic chemical probes. Müller S and Brown PJ

Clin. Pharmacol. Ther. 92(6) , 689-93, (2012)

Targeting chromatin readers. James LI and Frye SV

Clin. Pharmacol. Ther. 93(4) , 312-4, (2013)

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)-

2-Methyl-2-propanyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate

(R)-(-)-JQ1 Enantiomer