CL2A-SN-38

Modify Date: 2024-01-30 09:43:45

CL2A-SN-38 Structure
CL2A-SN-38 structure
Common Name CL2A-SN-38
CAS Number 1279680-68-0 Molecular Weight 1480.61
Density N/A Boiling Point N/A
Molecular Formula C73H97N11O22 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CL2A-SN-38


CL2A-SN-38, SN-38 (topoisomerase-I inhibitor) derivative, is a peptide linker. CL2A-SN-38 is conjugated to the anti-Trop-2-humanized antibody, SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, provides significant and specific antitumor effects against a range of human solid tumor types[1].

 Names

Name CL2A-SN-38

 CL2A-SN-38 Biological Activity

Description CL2A-SN-38, SN-38 (topoisomerase-I inhibitor) derivative, is a peptide linker. CL2A-SN-38 is conjugated to the anti-Trop-2-humanized antibody, SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, provides significant and specific antitumor effects against a range of human solid tumor types[1].
Related Catalog
Target

Alkyl/ether

References

[1]. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

 Chemical & Physical Properties

Molecular Formula C73H97N11O22
Molecular Weight 1480.61