3-(3-Phenoxybenzyl)amino-β-carboline

Modify Date: 2024-09-11 06:26:35

3-(3-Phenoxybenzyl)amino-β-carboline Structure
3-(3-Phenoxybenzyl)amino-β-carboline structure
Common Name 3-(3-Phenoxybenzyl)amino-β-carboline
CAS Number 1327080-54-5 Molecular Weight 365.43
Density N/A Boiling Point N/A
Molecular Formula C24H19N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 3-(3-Phenoxybenzyl)amino-β-carboline


3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity[1].

 Names

Name 3-(3-Phenoxybenzyl)amino-β-carboline

 3-(3-Phenoxybenzyl)amino-β-carboline Biological Activity

Description 3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity[1].
Related Catalog
In Vitro 3-(3-Phenoxybenzyl)amino-β-carboline specifically denatures tubulin, making it prone to aggregation that predisposes it to ubiquitinylation and then degradation[1].
References

[1]. Yang J, et al. Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J Med Chem. 2022 Jun 28.

 Chemical & Physical Properties

Molecular Formula C24H19N3O
Molecular Weight 365.43