1327080-54-5

1327080-54-5 structure

Name: 3-(3-Phenoxybenzyl)amino-β-carboline
Chemical Name: 3-(3-Phenoxybenzyl)amino-β-carboline
CAS Number: 1327080-54-5
Molecular Formula: C₂₄H₁₉N₃O
Molecular Weight: 365.43
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-07 17:59:53
Modify Date: 2024-09-11 06:26:35
3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity[1].

Name	3-(3-Phenoxybenzyl)amino-β-carboline

Description	3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	3-(3-Phenoxybenzyl)amino-β-carboline specifically denatures tubulin, making it prone to aggregation that predisposes it to ubiquitinylation and then degradation[1].
References	[1]. Yang J, et al. Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J Med Chem. 2022 Jun 28.

Molecular Formula	C₂₄H₁₉N₃O
Molecular Weight	365.43