2'-OMe-U Phosphoramidite

Modify Date: 2024-01-03 19:05:00

2'-OMe-U Phosphoramidite Structure
2'-OMe-U Phosphoramidite structure
Common Name 2'-OMe-U Phosphoramidite
CAS Number 134031-86-0 Molecular Weight 760.81
Density N/A Boiling Point N/A
Molecular Formula C40H49N4O9P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2'-OMe-U Phosphoramidite


3’-O-DMTr-thymidine 5’-CE phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 3-[[(2R,3S,5R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphoryl]oxypropanenitrile
Synonym More Synonyms

 2'-OMe-U Phosphoramidite Biological Activity

Description 3’-O-DMTr-thymidine 5’-CE phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Molecular Formula C40H49N4O9P
Molecular Weight 760.81
Exact Mass 744.32900
PSA 150.86000
LogP 6.81958

 Synonyms

5′-O-[(Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3′-O-(4,4′-dimethoxytrityl)thymidine
2'-OMe-UPhosphoramidite
5'-O-[(Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-dimethoxytrityl)thymidine
2'-OMe-U Phosphoramidite
DMT-dT-CE Reverse Phosphoramidite
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