Acid-C2-PEG4-C2-NHS ester

Modify Date: 2024-04-05 21:21:41

Acid-C2-PEG4-C2-NHS ester Structure
Acid-C2-PEG4-C2-NHS ester structure
Common Name Acid-C2-PEG4-C2-NHS ester
CAS Number 1343476-41-4 Molecular Weight 435.423
Density 1.3±0.1 g/cm3 Boiling Point 574.8±60.0 °C at 760 mmHg
Molecular Formula C18H29NO11 Melting Point N/A
MSDS N/A Flash Point 301.5±32.9 °C

 Use of Acid-C2-PEG4-C2-NHS ester


Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 19-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-19-oxo-4,7,10,13,16-pentaoxanonadecan-1-oic acid
Synonym More Synonyms

 Acid-C2-PEG4-C2-NHS ester Biological Activity

Description Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 574.8±60.0 °C at 760 mmHg
Molecular Formula C18H29NO11
Molecular Weight 435.423
Flash Point 301.5±32.9 °C
Exact Mass 435.174072
LogP -3.42
Vapour Pressure 0.0±3.4 mmHg at 25°C
Index of Refraction 1.509

 Safety Information

Hazard Codes Xi

 Synonyms

19-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-19-oxo-4,7,10,13,16-pentaoxanonadecan-1-oic acid
4,7,10,13,16-Pentaoxanonadecan-1-oic acid, 19-[(2,5-dioxo-1-pyrrolidinyl)oxy]-19-oxo-
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