GS-443902 trisodium
Modify Date: 2024-01-08 17:03:17
GS-443902 trisodium structure
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Common Name | GS-443902 trisodium | ||
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| CAS Number | 1355050-21-3 | Molecular Weight | 597.15 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H13N5Na3O13P3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GS-443902 trisodiumGS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2]. |
| Name | GS-443902 trisodium |
|---|
| Description | GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2]. |
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| Related Catalog | |
| Target |
IC50: 1.1 µM (RSV RdRp) and 5 µM (HCV RdRp)[1][2] |
| In Vitro | In a continuous 72 h incubation of 1 µM Remdesivir (GS-5734), the GS-443902 trisodium (GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium) level is measured at 2, 24, 48 and 72 h, and reaches a Cmax of 300, 110, and 90 pmol/million cells in macrophages, HMVEC, and HeLa cells lines respectively[1]. GS-443902 trisodium (compound 8a) is a triphosphates (TP) derivative[2]. GS-443902 trisodium (NTP; 0.01, 0.1, 1, 10, 100 μM) inhibits RSV RdRp-catalysed RNA synthesis by incorporating into the nascent viral RNA transcript and causing its premature termination. GS-5734 selectively inhibits EBOV replication by targeting its RdRp and inhibiting viral RNA synthesis following efficient intracellular conversion to GS-443902 sodium[3]. |
| In Vivo | Remdesivir (GS-5734; 10 mg kg; i.v.) rapidly distributes into peripheral blood mononuclear cells (PBMCs), and efficient conversion to GS-443902 trisodium (Remdesivir metabolite trisodium; NTP) is apparent within 2 h of dose administration in rhesus monkeys. In PBMCs, GS-443902 trisodium represents the predominant metabolite and is persistent with a t1/2 of 14 h and levels required for >50% virus inhibition for 24 hours[3]. |
| References |
| Molecular Formula | C12H13N5Na3O13P3 |
|---|---|
| Molecular Weight | 597.15 |