UBE2T/FANCL-IN-1

Modify Date: 2024-01-11 19:20:02

UBE2T/FANCL-IN-1 structure	Common Name	UBE2T/FANCL-IN-1
	CAS Number	1359415-02-3	Molecular Weight	357.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₃₁N₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of UBE2T/FANCL-IN-1

UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1].

Name	UBE2T/FANCL-IN-1

Description	UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	UBE2T/FANCL-IN-1 (CU2) completely inhibits the ubiquitylation of GST-FANCLRING at 100 μM. UBE2T/FANCL-IN-1 (500 μM) reduced the level of mUb-FANCD2 in response to HU treatment. UBE2T/FANCL-IN-1 (500 μM) also reducesthe level of mUb-FANCD2 generated in response to Cisplatin (10 μM) treatment for 6, 12, and 24 hours. The combination of 250 μM UBE2T/FANCL-IN-1 with 15 μM carboplatin led to an even more pronounced decrease in cell proliferation/growth, with the cells being <50% confluent after 8 days[1].
References	[1]. Cornwell MJ, et al. Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway. ACS Chem Biol. 2019;14(10):2148-2154.

Molecular Formula	C₁₉H₃₁N₇
Molecular Weight	357.50

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: UBE2T/FANCL-IN-1
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: UBE2T/FANCL-IN-1
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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