1359415-02-3
1359415-02-3 structure
- Name: UBE2T/FANCL-IN-1
- Chemical Name: UBE2T/FANCL-IN-1
- CAS Number: 1359415-02-3
- Molecular Formula: C19H31N7
- Molecular Weight: 357.50
- Catalog: Research Areas Cancer
- Create Date: 2022-01-05 19:00:57
- Modify Date: 2024-01-11 19:20:02
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UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1].
| Name | UBE2T/FANCL-IN-1 |
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| Description | UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1]. |
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| Related Catalog | |
| In Vitro | UBE2T/FANCL-IN-1 (CU2) completely inhibits the ubiquitylation of GST-FANCLRING at 100 μM. UBE2T/FANCL-IN-1 (500 μM) reduced the level of mUb-FANCD2 in response to HU treatment. UBE2T/FANCL-IN-1 (500 μM) also reducesthe level of mUb-FANCD2 generated in response to Cisplatin (10 μM) treatment for 6, 12, and 24 hours. The combination of 250 μM UBE2T/FANCL-IN-1 with 15 μM carboplatin led to an even more pronounced decrease in cell proliferation/growth, with the cells being <50% confluent after 8 days[1]. |
| References |
| Molecular Formula | C19H31N7 |
|---|---|
| Molecular Weight | 357.50 |