AMG-1694
Modify Date: 2024-01-10 17:42:28
AMG-1694 structure
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Common Name | AMG-1694 | ||
|---|---|---|---|---|
| CAS Number | 1361217-07-3 | Molecular Weight | 533.63 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H30F3N3O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AMG-1694AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. |
| Name | AMG-1694 |
|---|
| Description | AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. |
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| Related Catalog | |
| Target |
IC50: 7 nM (GK-GKRP)[1] |
| In Vitro | AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50 of 0.020 μM in the presence of GKRP[1]. |
| References |
| Molecular Formula | C23H30F3N3O4S2 |
|---|---|
| Molecular Weight | 533.63 |