GSK2646264

Modify Date: 2024-01-02 12:36:56

GSK2646264 structure	Common Name	GSK2646264
	CAS Number	1398695-47-0	Molecular Weight	374.48
	Density	1.1±0.1 g/cm3	Boiling Point	517.4±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₆N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	266.7±30.1 °C

Use of GSK2646264

GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.1. GSK2646264 also inhibits other kinases with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin[1].

Name	GSK2646264
Synonym	More Synonyms

Description	GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.1. GSK2646264 also inhibits other kinases with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> Autophagy >> LRRK2 Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	SYK:7.1 (pIC50) LCK:5.4 (pIC50) LRRK2:5.4 (pIC50) GSK3β:5.3 (pIC50) JAK2:5 (pIC50) VEGFR2:4.5 (pIC50) Aurora B:<4.6 (pIC50) Aurora A:<4.3 (pIC50)
References	[1]. Barker MD, et al. Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3458-3462.

Density	1.1±0.1 g/cm3
Boiling Point	517.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₆N₂O₂
Molecular Weight	374.48
Flash Point	266.7±30.1 °C
Exact Mass	374.199432
LogP	3.40
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.585

7-{2-Methoxy-6-[(4-methyl-2-pyridinyl)methoxy]phenyl}-2,3,4,5-tetrahydro-1H-3-benzazepine

1H-3-Benzazepine, 2,3,4,5-tetrahydro-7-[2-methoxy-6-[(4-methyl-2-pyridinyl)methoxy]phenyl]-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GSK2646264
Price: Click To Check
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: GSK2646264
Price: $1500.0/10mg
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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GSK2646264

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