NSC 625987

Modify Date: 2024-01-14 19:02:29

NSC 625987 Structure
NSC 625987 structure
Common Name NSC 625987
CAS Number 141992-47-4 Molecular Weight 271.33400
Density 1.32g/cm3 Boiling Point 460.4ºC at 760 mmHg
Molecular Formula C15H13NO2S Melting Point N/A
MSDS N/A Flash Point 232.2ºC

 Use of NSC 625987


NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].

 Names

Name 1,4-dimethoxy-10H-acridine-9-thione
Synonym More Synonyms

 NSC 625987 Biological Activity

Description NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].
Related Catalog
Target

CDK4/D1:0.2 μM (IC50)

In Vitro NSC 625987 (10 nM, 50 nM, 100 nM) treatment attenuates the enhanced proliferation of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) rats by about 35%[2].
References

[1]. A Kubo, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5(12):4279-86.

[2]. Jasmine El Andalousi, et al.Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling. PLoS One. 2013 Oct 14;8(10):e76183.

 Chemical & Physical Properties

Density 1.32g/cm3
Boiling Point 460.4ºC at 760 mmHg
Molecular Formula C15H13NO2S
Molecular Weight 271.33400
Flash Point 232.2ºC
Exact Mass 271.06700
PSA 66.34000
LogP 4.06780
Vapour Pressure 1.17E-08mmHg at 25°C
Index of Refraction 1.683

 Synonyms

1,4-Dimethoxy-9-thio(10H)-acridone
Tocris-2152
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