NSC 625987 structure
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Common Name | NSC 625987 | ||
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CAS Number | 141992-47-4 | Molecular Weight | 271.33400 | |
Density | 1.32g/cm3 | Boiling Point | 460.4ºC at 760 mmHg | |
Molecular Formula | C15H13NO2S | Melting Point | N/A | |
MSDS | N/A | Flash Point | 232.2ºC |
Use of NSC 625987NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1]. |
Name | 1,4-dimethoxy-10H-acridine-9-thione |
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Synonym | More Synonyms |
Description | NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1]. |
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Related Catalog | |
Target |
CDK4/D1:0.2 μM (IC50) |
In Vitro | NSC 625987 (10 nM, 50 nM, 100 nM) treatment attenuates the enhanced proliferation of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) rats by about 35%[2]. |
References |
Density | 1.32g/cm3 |
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Boiling Point | 460.4ºC at 760 mmHg |
Molecular Formula | C15H13NO2S |
Molecular Weight | 271.33400 |
Flash Point | 232.2ºC |
Exact Mass | 271.06700 |
PSA | 66.34000 |
LogP | 4.06780 |
Vapour Pressure | 1.17E-08mmHg at 25°C |
Index of Refraction | 1.683 |
~84% NSC 625987 CAS#:141992-47-4 |
Literature: Arzneimittel-Forschung/Drug Research, , vol. 42, # 5 p. 674 - 679 |
~% NSC 625987 CAS#:141992-47-4 |
Literature: Annales Pharmaceutiques Francaises, , vol. 54, # 1 p. 27 - 33 |
~% NSC 625987 CAS#:141992-47-4 |
Literature: Annales Pharmaceutiques Francaises, , vol. 54, # 1 p. 27 - 33 |
~% NSC 625987 CAS#:141992-47-4 |
Literature: Annales Pharmaceutiques Francaises, , vol. 54, # 1 p. 27 - 33 |
1,4-Dimethoxy-9-thio(10H)-acridone |
Tocris-2152 |