Cidofovir diphosphate

Modify Date: 2024-01-08 20:58:02

Cidofovir diphosphate Structure
Cidofovir diphosphate structure
Common Name Cidofovir diphosphate
CAS Number 142276-31-1 Molecular Weight 439.15
Density N/A Boiling Point N/A
Molecular Formula C8H16N3O12P3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cidofovir diphosphate


Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively[1][2].

 Names

Name Cidofovir diphosphate

 Cidofovir diphosphate Biological Activity

Description Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively[1][2].
Related Catalog
Target

Viral DNA polymerase[1]

References

[1]. Hitchcock MJM, et al. Cidofovir, a New Agent with Potent Anti-Herpesvirus Activity. 1996.

[2]. Magee WC, et al. Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate. Antimicrob Agents Chemother. 2005 Aug;49(8):3153-62.  

 Chemical & Physical Properties

Molecular Formula C8H16N3O12P3
Molecular Weight 439.15
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