Mutant IDH1-IN-2
Modify Date: 2024-01-09 15:44:25
Mutant IDH1-IN-2 structure
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Common Name | Mutant IDH1-IN-2 | ||
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| CAS Number | 1429176-69-1 | Molecular Weight | 459.532 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 578.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C24H31F2N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 303.4±32.9 °C | |
Use of Mutant IDH1-IN-2Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.Target: Mutant IDH1Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. More bioactivity information in Patent WO 2013046136A1 (Example 224). |
| Name | Mutant IDH1-IN-2 |
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| Synonym | More Synonyms |
| Description | Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.Target: Mutant IDH1Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. More bioactivity information in Patent WO 2013046136A1 (Example 224). |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 578.1±60.0 °C at 760 mmHg |
| Molecular Formula | C24H31F2N5O2 |
| Molecular Weight | 459.532 |
| Flash Point | 303.4±32.9 °C |
| Exact Mass | 459.244568 |
| LogP | 2.72 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.587 |
| Storage condition | 2-8℃ |
| (4S)-3-(2-{[(1S)-1-{4-[(4,4-Difluoro-1-piperidinyl)methyl]phenyl}ethyl]amino}-4-pyrimidinyl)-4-isopropyl-1,3-oxazolidin-2-one |
| 2-Oxazolidinone, 3-[2-[[(1S)-1-[4-[(4,4-difluoro-1-piperidinyl)methyl]phenyl]ethyl]amino]-4-pyrimidinyl]-4-(1-methylethyl)-, (4S)- |