IDH-889

Modify Date: 2024-01-11 20:17:31

IDH-889 Structure
IDH-889 structure
 Common Name IDH-889
CAS Number 1429179-07-6 Molecular Weight 436.48
Density N/A Boiling Point N/A
Molecular Formula C23H25FN6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IDH-889


IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].

 Names

Name IDH889

 IDH-889 Biological Activity

Description IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].
Related Catalog
Target

IC50: 0.02 μM (IDH1R132H), 0.072 μM (IDH1R132C), 1.38 μM (IDH1wt)[1]

References

[1]. Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8(2):151-156.

 Chemical & Physical Properties

Molecular Formula C23H25FN6O2
Molecular Weight 436.48
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Chemsrc provides IDH-889(CAS#:1429179-07-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of IDH-889 are included as well.>> amp version: IDH-889

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