Hydroxy Pioglitazone
Modify Date: 2024-01-05 09:18:30
Hydroxy Pioglitazone structure
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Common Name | Hydroxy Pioglitazone | ||
|---|---|---|---|---|
| CAS Number | 146062-44-4 | Molecular Weight | 372.438 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 627.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C19H20N2O4S | Melting Point | 157-158ºC | |
| MSDS | N/A | Flash Point | 333.4±31.5 °C | |
Use of Hydroxy PioglitazoneLeriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone.Leriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy.Leriglitazone (Hydroxypioglitazone) binds to the PPARγ C-terminal ligand-binding domain (LBD) with Ki of 1.2 μM，induces transcriptional efficacy of the PPARγ (LBD) with EC50 of 680 nM[1]. |
| Name | Hydroxy Pioglitazone |
|---|---|
| Synonym | More Synonyms |
| Description | Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone.Leriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy.Leriglitazone (Hydroxypioglitazone) binds to the PPARγ C-terminal ligand-binding domain (LBD) with Ki of 1.2 μM，induces transcriptional efficacy of the PPARγ (LBD) with EC50 of 680 nM[1]. |
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| Related Catalog | |
| Target |
Ki: 1.2 μM (PPARγ LBD); EC: 680 nM (PPARγ LBD) (Leriglitazone)[1] |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 627.6±55.0 °C at 760 mmHg |
| Melting Point | 157-158ºC |
| Molecular Formula | C19H20N2O4S |
| Molecular Weight | 372.438 |
| Flash Point | 333.4±31.5 °C |
| Exact Mass | 372.114380 |
| PSA | 113.82000 |
| LogP | 1.11 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.628 |
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| 5-(4-{2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione |
| 2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]- |
| 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione |
| Pioglitazone Impurity 18 |