1-Hydroxy Pioglitazone Hydrochloride
Modify Date: 2024-01-02 11:20:23
1-Hydroxy Pioglitazone Hydrochloride structure
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Common Name | 1-Hydroxy Pioglitazone Hydrochloride | ||
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| CAS Number | 146062-46-6 | Molecular Weight | 408.90 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H21ClN2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 1-Hydroxy Pioglitazone HydrochlorideLeriglitazone (Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) hydrochloride PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) hydrochloride binds to the PPARγ C-terminal ligand-binding domain (LBD) with a Ki of 1.2 μM，Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC50 of 680 nM[1]. |
| Name | 5-(4-{2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | Leriglitazone (Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) hydrochloride PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) hydrochloride binds to the PPARγ C-terminal ligand-binding domain (LBD) with a Ki of 1.2 μM，Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC50 of 680 nM[1]. |
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| Related Catalog | |
| Target |
PPAR-γ |
| References |
| Molecular Formula | C19H21ClN2O4S |
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| Molecular Weight | 408.90 |
| Exact Mass | 408.091064 |
| 5-(4-{2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione hydrochloride (1:1) |
| 2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-, hydrochloride (1:1) |