N-Acetyl-Val-Ala-Asp-al

Modify Date: 2024-01-04 07:53:34

N-Acetyl-Val-Ala-Asp-al structure	Common Name	N-Acetyl-Val-Ala-Asp-al
	CAS Number	147837-52-3	Molecular Weight	329.349
	Density	1.2±0.1 g/cm3	Boiling Point	698.2±55.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₂₃N₃O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	376.0±31.5 °C

Use of N-Acetyl-Val-Ala-Asp-al

Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells[1].

Name	(3S)-3-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
Synonym	More Synonyms

Description	Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase
References	[1]. Jee-Youn Kim, et al. ROS-dependent caspase-9 activation in hypoxic cell death. FEBS Lett. 2003 Aug 14;549(1-3):94-8.

Density	1.2±0.1 g/cm3
Boiling Point	698.2±55.0 °C at 760 mmHg
Molecular Formula	C₁₄H₂₃N₃O₆
Molecular Weight	329.349
Flash Point	376.0±31.5 °C
Exact Mass	329.158691
PSA	141.67000
LogP	-0.05
Vapour Pressure	0.0±4.7 mmHg at 25°C
Index of Refraction	1.498
Storage condition	−20°C

N-Acetyl-Val-Ala-Asp-al MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation.

Autophagy 7 , 217-228, (2011)

The treatment of L929 fibrosarcoma cells with zVAD has been shown to induce necroptosis. However, whether autophagy is involved or not in this event remains controversial. In this study, we re-examine...

Inhibition of human caspases by peptide-based and macromolecular inhibitors.

J. Biol. Chem. 273 , 32608-32613, (1998)

Studies with peptide-based and macromolecular inhibitors of the caspase family of cysteine proteases have helped to define a central role for these enzymes in inflammation and mammalian apoptosis. A c...

Caspase activation by BCR cross-linking in immature B cells: differential effects on growth arrest and apoptosis.

FASEB J. 13 , 931-944, (1999)

The B cell lymphoma WEHI-231 has been used as a model to study immature B cell tolerance, based on its capacity to undergo growth arrest and programmed cell death on B cell receptor (BCR) cross-linkin...

Ac-VAD-CHO

N-acetyl-L-valyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-alaninamide

N-Acetyl-Val-Ala-Asp-al

L-Alaninamide,N-acetyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-(9CI)

L-Alaninamide, N-acetyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-

N-Acetyl-L-valyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-alaninamide

Ac-Val-Ala-Asp-CHO

L-alaninamide,N-acetyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]

Caspase Inhibitor II

L-Alaninamide,N-acetyl-L-valyl-N-(2-carboxy-1-formylethyl)-,(S)