(S)-Seco-Duocarmycin SA

Modify Date: 2024-01-03 12:15:26

(S)-Seco-Duocarmycin SA Structure
(S)-Seco-Duocarmycin SA structure
Common Name (S)-Seco-Duocarmycin SA
CAS Number 152785-82-5 Molecular Weight 513.927
Density 1.5±0.1 g/cm3 Boiling Point 773.9±60.0 °C at 760 mmHg
Molecular Formula C25H24ClN3O7 Melting Point N/A
MSDS N/A Flash Point 421.8±32.9 °C

 Use of (S)-Seco-Duocarmycin SA


(S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates[1].

 Names

Name Methyl (8S)-8-(chloromethyl)-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carboxylate
Synonym More Synonyms

 (S)-Seco-Duocarmycin SA Biological Activity

Description (S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates[1].
Related Catalog
References

[1]. Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129(35):10858-69.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 773.9±60.0 °C at 760 mmHg
Molecular Formula C25H24ClN3O7
Molecular Weight 513.927
Flash Point 421.8±32.9 °C
Exact Mass 513.130249
LogP 1.54
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.691

 Synonyms

Methyl (8S)-8-(chloromethyl)-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carboxylate
Pyrrolo[3,2-e]indole-2-carboxylic acid, 8-(chloromethyl)-3,6,7,8-tetrahydro-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (8S)-