Duocarmycin SA

Modify Date: 2024-01-06 20:08:49

Duocarmycin SA structure	Common Name	Duocarmycin SA
	CAS Number	130288-24-3	Molecular Weight	477.46600
	Density	1.53±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₃N₃O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Duocarmycin SA

Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2].

Name	(+)-duocarmycin SA
Synonym	More Synonyms

Description	Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
References	[1]. MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. [2]. Boyle KE, et al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2688-2692.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

References

[1]. MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5.

[2]. Boyle KE, et al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2688-2692.

Density	1.53±0.1 g/cm3
Molecular Formula	C₂₅H₂₃N₃O₇
Molecular Weight	477.46600
Exact Mass	477.15400
PSA	122.95000
LogP	2.74020
Vapour Pressure	8.82E-25mmHg at 25°C
Water Solubility	Practically insoluble (0.03 g/L) (25 ºC)

Duocarmycin SA

Antibiotic DC 113

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Duocarmycin SA
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Duocarmycin SA
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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