130288-24-3

130288-24-3 structure

Name: Duocarmycin SA
Chemical Name: (+)-duocarmycin SA
CAS Number: 130288-24-3
Molecular Formula: C₂₅H₂₃N₃O₇
Molecular Weight: 477.46600
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2017-06-04 00:28:25
Modify Date: 2024-01-06 20:08:49
Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2].

Name	(+)-duocarmycin SA
Synonyms	Duocarmycin SA Antibiotic DC 113

Description	Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
References	[1]. MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. [2]. Boyle KE, et al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2688-2692.