CC-17369

Modify Date: 2024-01-16 10:21:51

CC-17369 Structure
CC-17369 structure
Common Name CC-17369
CAS Number 1547162-46-8 Molecular Weight 289.24
Density 1.7±0.1 g/cm3 Boiling Point 649.7±55.0 °C at 760 mmHg
Molecular Formula C13H11N3O5 Melting Point N/A
MSDS N/A Flash Point 346.7±31.5 °C

 Use of CC-17369


CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC[1].

 Names

Name CC-17369
Synonym More Synonyms

 CC-17369 Biological Activity

Description CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC[1].
Related Catalog
Target

Cereblon

References

[1]. Hoffmann M, et al. Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol. 2013;71(2):489-501.

[2]. Makbul C, et al. Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife. 2020;9:e57277. Published 2020 Aug 14.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 649.7±55.0 °C at 760 mmHg
Molecular Formula C13H11N3O5
Molecular Weight 289.24
Flash Point 346.7±31.5 °C
Exact Mass 289.069885
LogP -1.97
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.725

 Safety Information

Hazard Codes Xi

 Synonyms

1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-7-hydroxy-
CC-17369
4-Amino-2-(2,6-dioxo-3-piperidinyl)-7-hydroxy-1H-isoindole-1,3(2H)-dione
2Z346T86O9
UNII:2Z346T86O9