CC 1014

Modify Date: 2024-01-10 12:10:06

CC 1014 structure	Common Name	CC 1014
	CAS Number	76600-38-9	Molecular Weight	1218.61000
	Density	1.116g/cm3	Boiling Point	1408ºC at 760 mmHg
	Molecular Formula	C₆₂H₁₁₁N₁₁O₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	805.3ºC

Use of CC 1014

Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies[1].

Name	.β.-Alaninamide, cis-4-methyl-1-(4-methyl-1-oxo-2-hexenyl)- L-prolyl-(4S,6S)-6-hydroxy-4-methyl-8-oxo- L-2-aminodecanoyl-threo-3-hydroxy-L-leucyl- 2-methylalanyl-L-leucyl-L-leucyl-2-methylalanyl- 2-methylalanyl-N-[2-(dimethylamino)-1-methylethyl]-, [1[

Description	Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
References	[1]. Csermely P, et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim Biophys Acta. 1994;1221(2):125-132. [2]. Ricci M, et al. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Int J Pharm. 2004;275(1-2):61-72. [3]. Brand M, et al. Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

References

[1]. Csermely P, et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim Biophys Acta. 1994;1221(2):125-132.

[2]. Ricci M, et al. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Int J Pharm. 2004;275(1-2):61-72.

[3]. Brand M, et al. Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621.

Density	1.116g/cm3
Boiling Point	1408ºC at 760 mmHg
Molecular Formula	C₆₂H₁₁₁N₁₁O₁₃
Molecular Weight	1218.61000
Flash Point	805.3ºC
Exact Mass	1217.84000
PSA	342.98000
LogP	5.73340
Index of Refraction	1.515

Precursor 0
DownStream 6
CAS#:61-90-5 L-leucine CAS#:79026-24-7 (2S,4R,6R)-4-me... CAS#:70831-55-9 (2S)-N1,N1-dime... CAS#:107-95-9 beta-Alanine
CAS#:6734-41-4 Cis methyl-4 L-... CAS#:62-57-7 2-Aminoisobutyr...