Cisplatin

Modify Date: 2024-01-02 19:00:39

Cisplatin Structure
Cisplatin structure
 Common Name Cisplatin
CAS Number 15663-27-1 Molecular Weight 300.05
Density 3.7 Boiling Point N/A
Molecular Formula Cl2H6N2Pt Melting Point 270ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS05 GHS06 GHS08
GHS05, GHS06, GHS08		 Signal Word Danger

 Use of Cisplatin


Cisplatin is a antineoplastic chemotherapy drug which works by cross-linking with DNA and causing DNA damage in cancer cells.

 Names

Name cisplatin
Synonym More Synonyms

 Cisplatin Biological Activity

Description Cisplatin is a antineoplastic chemotherapy drug which works by cross-linking with DNA and causing DNA damage in cancer cells.
Related Catalog
Target

DNA Alkylator/Crosslinker[1]

In Vitro Cisplatin (CDDP) causes apoptosis of HeLa cells in a dose-dependent manner, with a concentration of 30 μM Cisplatin resulting in death of greater than 90% of the cell population by 24 h of treatment. The kinetics of Cisplatin-induced apoptosis are examined using a 30 μM concentration. Cisplatin Activates the MEK/ERK Signaling Pathway, 20 and 30 μM Cisplatin, both of which results in significant apoptosis, leads to strong activation of ERK[1]. Cisplatin (50 μM) produces time-dependent apoptosis in renal proximal tubular cell (RPTCs), causing cell shrinkage, a 50-fold increase in caspase 3 activity, a 4-fold increase in phosphatidylserine externalization, and 5- and 15-fold increases in chromatin condensation and DNA hypoploidy, respectively[2].
In Vivo In melanoma-bearing mice, Cisplatin (4 mg/kg B.W.) reduces the size and weight of the solid tumors, and HemoHIM supplementation with Cisplatin enhances the decrease of both the tumor size and weight[3]. Cisplatin administration results in significant increases in the kidney weight as a percentage of the total body weight, urine volume, serum creatinine, and blood urea nitrogenby about 132, 315, 797, and 556% in comparison with the control rats, respectively[4].
Cell Assay HeLa and A549 cells are maintained in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum, 100 units of Penicillin, and 100 μg of Streptomycin/mL. They are cultured at 37°C in a humidified chamber containing 5% CO2. For the induction of apoptosis, cells are plated in 60-mm dishes 1 day prior to Cisplatin (0-30 μM) treatment[1].
Animal Admin Mice[3] Mice are divided randomly into three groups (Control, Cisplatin and Cisplatin+HemoHIM), and each group consists of twenty mice. B16F0 melanoma (5×105 cells/mouse) is inoculated into subcutaneous femoral left region of mice at 3 days before an initial injection of Cisplatin. Cisplatin is injected intraperitoneally at 4 mg/kg body weight (B.W.) on day 0, 7 and 14 (total three injections). Experimental group is intubated with HemoHIM at a final concentration of 100 mg/kgB.W. by everyday from day -1 to day 16, while the control group received only water. On day 17 after initial injection of Cisplatin, all mice of each group are experimented, respectively, to evaluate tumor weight or tumor size. The tumor size is calculated as follows: tumor size=ab2/2, where a and b are the larger and smaller diameters, respectively. Rats[4] Male Sprague-Dawley rats weighing 200 to 250 g are divided at random into 4 groups of 4 or 5 animals each. The first group (control) received a vehicle (5% carboxymethyl cellulose sodium solution (CMC-Na), 5 mL/kg body wt., p.o.) used for Capsaicin (Cap). The second group received Cap (10 mg/kg/d, p.o.) in 5% CMC-Na (5 mL/kg), and the third received 5% CMC-Na for 6 consecutive days injected with Cisplatin (5 mg/kg in physiological saline solution, i.p.). The fourth group received Cap (10 mg/kg/d, p.o.) in 5% CMC-Na for 6 consecutive days after Cisplatin injection (5 mg/kg, i.p.). For all groups, Cap or vehicle is given twice daily. The selected Cap concentration and the dose administration schedule without inducing any rat intestinal damage are chosen using data from our preliminary experiments.
References

[1]. Wang X, et al. Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem. 2000 Dec 15;275(50):39435-43.

[2]. Cummings BS, et al. Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways. J Pharmacol Exp Ther. 2002 Jul;302(1):8-17.

[3]. Park HR, et al. Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice. BMC Cancer. 2009 Mar 17;9:85.

[4]. Shimeda Y, et al. Protective effects of capsaicin against cisplatin-induced nephrotoxicity in rats. Biol Pharm Bull. 2005 Sep;28(9):1635-8.

[5]. Hall MD, et al. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. Cancer Res. 2014 Jul 15;74(14):3913-22.

[6]. Wu K, et al. Cisplatin inhibits the progression of bladder cancer by selectively depleting G-MDSCs: A novel chemoimmunomodulating strategy. Clin Immunol. 2018 Aug;193:60-69.

 Chemical & Physical Properties

Density 3.7
Melting Point 270ºC
Molecular Formula Cl2H6N2Pt
Molecular Weight 300.05
PSA 52.04000
LogP 1.59590
Storage condition Store at RT
Stability Stable. Incompatible with oxidizing agents, aluminium, antioxidants.
Water Solubility <0.1 g/100 mL at 19 ºC

 Safety Information

Symbol GHS05 GHS06 GHS08
GHS05, GHS06, GHS08
Signal Word Danger
Hazard Statements H300-H318-H350
Precautionary Statements P201-P264-P280-P301 + P310-P305 + P351 + P338-P308 + P313
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T:Toxic
Risk Phrases R45;R25;R41
Safety Phrases S53-S26-S39-S45
RIDADR UN 1851/3288
WGK Germany 3
RTECS TP2455000
Packaging Group II
Hazard Class 6.1(a)
HS Code 2932999099

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

trans--diamminedichloroplatinum(II)
trans-diamminodichloroplatinum(II)
UNII:Q20Q21Q62J
EINECS 239-733-8
Dichloroplatinum diammoniate
cis-Diamminedichloroplatinum(II)
cis-Diamineplatinum(II) dichloride
cis-Platinum(II) diammine dichloride
MFCD00011623
transplatin
trans-dichlorodiammineplatinum(II)
trans-dichlorodiamine platinum(II)
cis-Diammineplatinum(II) dichloride (cis-Dichlorodiammine platinum(II)
trans-Diamminedichloroplatinum(II) (trans-Dichlorodiammineplatinum(II)
cis-Diamminedichlorplatine
cis-Dichlorodiammine platinum(II)
cis-Dichlorodiamineplatinum(II)
cis-Diammineplatinum dichloride
trans-diaminedichloroplatinum(II)
cis-Diammineplatinum(II) dichloride
Cisplatin
trans-Platinum diammine dichloride
CIS-PLATIN
trans-Dichlorodiamineplatinum(II)
Cisplatin impurity A
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