BIBP3226 trifluoroacetate salt

Modify Date: 2024-01-12 22:26:22

BIBP3226 trifluoroacetate salt structure	Common Name	BIBP3226 trifluoroacetate salt
	CAS Number	159013-54-4	Molecular Weight	473.56700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₁N₅O₃	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of BIBP3226 trifluoroacetate salt

BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect[1][2].

Name	(2R)-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide
Synonym	More Synonyms

Description	BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
In Vivo	BIBP3226 (0.5, 5 μg; i.c.v.; male Wistar rats) induces an anxiogenic-like effect at the higher dose[1].
References	[1]. Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4.

Molecular Formula	C₂₇H₃₁N₅O₃
Molecular Weight	473.56700
Exact Mass	473.24300
PSA	140.33000
LogP	4.56130
Storage condition	-20°C

BIBP3226 trifluoroacetate salt MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

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J. Neurosci. 34(35) , 11769-80, (2014)

Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hip...

Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP 3226.

J. Pharmacol. Exp. Ther. 275 , 136-142, (1995)

The present study was undertaken to investigate the in vitro and in vivo pharmacological profile of the novel, nonpeptide neuropeptide Y (NPY) Y1-selective antagonist, BIBP 3226 [(R)-N2-(diphenylacety...

Selective inhibition of neuropeptide Y Y1 receptors by BIBP3226 in rat and human epithelial preparations.

Eur. J. Pharmacol. 310 , 55-60, (1996)

BIBP3226 (N2-(diphenylacetyl)-N-[4-hydroxyphenyl)methyl]-D-arginine amide) has been used to examine the presence of neuropeptide Y Y1 receptors in 3 gastrointestinal epithelial preparations, namely th...

BIBP3226

N2-(Diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D-arginine amide