Mal-PEG6-PFP ester

Modify Date: 2024-01-03 18:12:43

Mal-PEG6-PFP ester Structure
Mal-PEG6-PFP ester structure
Common Name Mal-PEG6-PFP ester
CAS Number 1599486-33-5 Molecular Weight 599.498
Density 1.4±0.1 g/cm3 Boiling Point 623.0±55.0 °C at 760 mmHg
Molecular Formula C25H30F5NO10 Melting Point N/A
MSDS N/A Flash Point 330.6±31.5 °C

 Use of Mal-PEG6-PFP ester


Mal-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Mal-PEG6-PFP
Synonym More Synonyms

 Mal-PEG6-PFP ester Biological Activity

Description Mal-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 623.0±55.0 °C at 760 mmHg
Molecular Formula C25H30F5NO10
Molecular Weight 599.498
Flash Point 330.6±31.5 °C
Exact Mass 599.179016
LogP 0.57
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.490

 Synonyms

MFCD22683307
3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,3,4,5,6-pentafluorophenyl ester
Pentafluorophenyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18-hexaoxahenicosan-21-oate
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