SCH 50911 hydrochloride

Modify Date: 2024-09-14 06:56:05

SCH 50911 hydrochloride Structure
SCH 50911 hydrochloride structure
Common Name SCH 50911 hydrochloride
CAS Number 160415-07-6 Molecular Weight 173.21000
Density 1.055 g/cm3 Boiling Point 305.5ºC at 760 mmHg
Molecular Formula C8H16ClNO3 Melting Point N/A
MSDS Chinese USA Flash Point 138.6ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of SCH 50911 hydrochloride


SCH 50911 hydrochloride, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 hydrochloride antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM.

 Names

Name (2s)-(+)-5,5-dimethyl-2-morpholineacetic acid
Synonym More Synonyms

 SCH 50911 hydrochloride Biological Activity

Description SCH 50911 hydrochloride, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 hydrochloride antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM.
Related Catalog
Target

GABA(B):1.1 μM (IC50)

References

[1]. Ong J, et al. The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor antagonist in rat neocortical slices. Eur J Pharmacol. 1998 Nov 27;362(1):35-41.

 Chemical & Physical Properties

Density 1.055 g/cm3
Boiling Point 305.5ºC at 760 mmHg
Molecular Formula C8H16ClNO3
Molecular Weight 173.21000
Flash Point 138.6ºC
Exact Mass 173.10500
PSA 58.56000
LogP 0.55690
Vapour Pressure 0.000187mmHg at 25°C
Index of Refraction 1.444

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317
Precautionary Statements P280
Hazard Codes Xi
RIDADR NONH for all modes of transport
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(+)-(2S)-5,5-Dimethyl-2-morpholineacetic acid hydrochloride
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