CDK8-IN-1
Modify Date: 2024-09-17 17:03:07
CDK8-IN-1 structure
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Common Name | CDK8-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1629633-48-2 | Molecular Weight | 255.20 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H8F3N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CDK8-IN-1CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. |
| Name | CDK8-IN-1 |
|---|
| Description | CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. |
|---|---|
| Related Catalog | |
| Target |
CDK8:3 nM (IC50) |
| In Vivo | CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1]. |
| Animal Admin | Mice[1] CDK8-IN-1 is administrated to mice with 5 mg/kg, 25mg/mg by IV and PO respectively[1]. |
| References |
| Molecular Formula | C11H8F3N3O |
|---|---|
| Molecular Weight | 255.20 |