CDK8-IN-1

Modify Date: 2024-09-17 17:03:07

CDK8-IN-1 structure	Common Name	CDK8-IN-1
	CAS Number	1629633-48-2	Molecular Weight	255.20
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₈F₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CDK8-IN-1

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

Name	CDK8-IN-1

Description	CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
Related Catalog	Research Areas >> Cancer
Target	CDK8:3 nM (IC50)
In Vivo	CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1].
Animal Admin	Mice[1] CDK8-IN-1 is administrated to mice with 5 mg/kg, 25mg/mg by IV and PO respectively[1].
References	[1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.

Molecular Formula	C₁₁H₈F₃N₃O
Molecular Weight	255.20

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CDK8-IN-1
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: CDK8-IN-1
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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