2457317-40-5

2457317-40-5 structure

2457317-40-5 structure

Name: CDK8-IN-10
Chemical Name: CDK8-IN-10
CAS Number: 2457317-40-5
Molecular Formula: C₂₅H₁₅ClF₃N₅O₃
Molecular Weight: 525.87
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-10-11 17:21:46
Modify Date: 2024-04-07 21:08:20
CDK8-IN-10 (compound 2) is a potent, selective cyclin-dependent kinase (CDK8) inhibitor with an IC50 value of 8.25 nM. CDK8-IN-10 can be used for research of cancer[1].

Name	CDK8-IN-10

Description	CDK8-IN-10 (compound 2) is a potent, selective cyclin-dependent kinase (CDK8) inhibitor with an IC50 value of 8.25 nM. CDK8-IN-10 can be used for research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK8:8.25 nM (IC50)
In Vitro	CDK8-IN-10 (compound 2; 8 h; SW620 cells) reduces phosphorylation of CDK8 substrate STAT1 in cells with an IC50 value of 1.3 µM[1].
References	[1]. Martínez-González S, et, al. Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors. Eur J Med Chem. 2020 Sep 1;201:112443.

Molecular Formula	C₂₅H₁₅ClF₃N₅O₃
Molecular Weight	525.87