2415156-30-6

2415156-30-6 structure

Name: CDK8-IN-7
Chemical Name: CDK8-IN-7
CAS Number: 2415156-30-6
Molecular Formula: C₃₀H₄₀N₂
Molecular Weight: 428.65
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-08-29 09:18:52
Modify Date: 2024-04-07 09:02:20
CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer[1].

Name	CDK8-IN-7

Description	CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK8:3.5 nM (Kd)
References	[1]. Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28(10):115461.

Molecular Formula	C₃₀H₄₀N₂
Molecular Weight	428.65