CDK8-IN-7

Modify Date: 2024-04-07 09:02:20

CDK8-IN-7 structure	Common Name	CDK8-IN-7
	CAS Number	2415156-30-6	Molecular Weight	428.65
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₄₀N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CDK8-IN-7

CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer[1].

Name	CDK8-IN-7

Description	CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK8:3.5 nM (Kd)
References	[1]. Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28(10):115461.

Molecular Formula	C₃₀H₄₀N₂
Molecular Weight	428.65

CDK8-IN-7

Use of CDK8-IN-7

Names

CDK8-IN-7 Biological Activity

Chemical & Physical Properties