DC-cholesterol hydrochloride

Modify Date: 2024-01-02 16:28:13

DC-cholesterol hydrochloride Structure
DC-cholesterol hydrochloride structure
Common Name DC-cholesterol hydrochloride
CAS Number 166023-21-8 Molecular Weight 537.26000
Density N/A Boiling Point N/A
Molecular Formula C32H57ClN2O2 Melting Point N/A
MSDS USA Flash Point N/A

 Use of DC-cholesterol hydrochloride


DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner[1][2].

 Names

Name Cholest-5-en-3-yl [2-(dimethylamino)ethyl]carbamate hydrochloride (1:1)
Synonym More Synonyms

 DC-cholesterol hydrochloride Biological Activity

Description DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner[1][2].
Related Catalog
References

[1]. Esmail A Elbassal, et al. Effects of Charged Cholesterol Derivatives on Aβ40 Amyloid Formation. J Phys Chem B. 2016 Jan 14;120(1):59-68.

[2]. Richard Lantz, et al. Effects of disulfide bond and cholesterol derivatives on human calcitonin amyloid formation. Biopolymers. 2020 May;111(5):e23343.

 Chemical & Physical Properties

Molecular Formula C32H57ClN2O2
Molecular Weight 537.26000
Exact Mass 536.41100
PSA 45.06000
LogP 8.69060

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles6

More Articles
In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE.

Gene Ther. 2 , 603-613, (1995)

Clinical trials using cationic liposome-mediated DNA transfer have now been initiated for several disorders including cystic fibrosis. Previous studies have shown that the level of gene expression ach...

Lipofection reagents prepared by a simple ethanol injection technique.

Biotechniques 18 , 1027-1032, (1995)

Cationic liposomes are being utilized for the delivery of DNA into mammalian cells both in vitro and in vivo. In this report, we describe a rapid, simple injection method for the preparation of cation...

The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors.

Gene Ther. 3 , 1026-1031, (1996)

An attempt was made to use simple cationic liposomes DC-Chol/DOPE and DDAB/DOPE (DC-Chol is 3 beta (N(N',N-dimethylaminoethane) carbamoyl) cholesterol, DDAB is dimethyldioctadecyl ammonium bromide and...

 Synonyms

2,3-dihydroxypropyl dihydrogen phosphate-cyclohexanamine(2:1)
DC-cholesterol hydrochloride
marinobufotoxin
3β-[N-(Dimethylaminoethane)­carbamoyl]­cholesterol
O-[(N,N-Dimethylaminoethyl)-carbamoyl]cholesterol hydrochloride