Digoxigenin

Modify Date: 2024-01-02 17:54:11

Digoxigenin Structure
Digoxigenin structure
Common Name Digoxigenin
CAS Number 1672-46-4 Molecular Weight 390.51300
Density 1.297 g/cm3 Boiling Point 589.4ºC at 760 mmHg
Molecular Formula C23H34O5 Melting Point 222 °C(lit.)
MSDS Chinese USA Flash Point 203ºC
Symbol GHS06
GHS06
Signal Word Danger

 Use of Digoxigenin


Digoxigenin is a hapten, a small molecule with high antigenicity, that is used in many molecular biology applications, as an alternative probe labeling for in situ hybridization

 Names

Name digoxigenin
Synonym More Synonyms

 Digoxigenin Biological Activity

Description Digoxigenin is a hapten, a small molecule with high antigenicity, that is used in many molecular biology applications, as an alternative probe labeling for in situ hybridization
Related Catalog

 Chemical & Physical Properties

Density 1.297 g/cm3
Boiling Point 589.4ºC at 760 mmHg
Melting Point 222 °C(lit.)
Molecular Formula C23H34O5
Molecular Weight 390.51300
Flash Point 203ºC
Exact Mass 390.24100
PSA 86.99000
LogP 2.57510
Vapour Pressure 2.4E-16mmHg at 25°C
Index of Refraction 1.609
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FH5390000
CHEMICAL NAME :
5-beta-Card-20(22)-enolide, 3-beta,12-beta,14-trihydroxy-
CAS REGISTRY NUMBER :
1672-46-4
BEILSTEIN REFERENCE NO. :
0096479
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C23-H34-O5
MOLECULAR WEIGHT :
390.57
WISWESSER LINE NOTATION :
L E5 B666TJ A1 DQ E1 F- DT5OV CUTJ IQ OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
244 ug/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
JPHAA3 Journal of the American Pharmaceutical Association. (Washington, DC) V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year: 27,189,1938
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
285 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,55,1963
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3545 ug/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - convulsions or effect on seizure threshold Cardiac - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,436,1965
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
1620 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 8,18,1960 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,190,1963

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H300-H310-H330
Precautionary Statements P260-P264-P280-P284-P302 + P350-P310
Hazard Codes T+: Very toxic;
Risk Phrases R26/27/28
Safety Phrases S36/37/39-S45
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS FH5390000
Packaging Group II
Hazard Class 6.1(a)

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 Synonyms

Lanadigenin
digitoxigenin
MFCD00871861
Lanadigigenin
3-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3,12,14-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
Digoxigenine
Digoxigenin
EINECS 216-806-2
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