Oxaprozin, potassium salt

Modify Date: 2024-01-22 06:40:05

Oxaprozin, potassium salt structure	Common Name	Oxaprozin, potassium salt
	CAS Number	174064-08-5	Molecular Weight	331.40700
	Density	N/A	Boiling Point	467ºC at 760mmHg
	Molecular Formula	C₁₈H₁₄KNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	236.2ºC

Use of Oxaprozin, potassium salt

Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2].

Name	potassium,3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoate
Synonym	More Synonyms

Description	Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:2.2 μM (IC50) COX-2:36 μM (IC50) NF-κB Akt pAKT IKK
In Vitro	Oxaprozin (0-100 μM) induces apoptosis in a dose-dependent manner. Oxaprozin increases caspase-3 activity in the activated but not in the resting condition. NF-κB activation is inhibited by Oxaprozin (50 μM). Oxaprozin inhibits activation of the IKK system induced by the reagent IκBα[1]. Oxaprozin (100 μM) induces the strongest proapoptotic effect and significantly increases CD40L-treated monocyte apoptosis. Oxaprozin treatment inhibits CD40L-induced Akt and NF-κB (p65) phosphorylation[2].
References	[1]. Ottonello L, et al. Delayed apoptosis of human monocytes exposed to immune complexes is reversed byoxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol. 2009 May;157(2):294-306. [2]. Montecucco F, et al. Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways. J Biomed Biotechnol. 2009;2009:478785.

Boiling Point	467ºC at 760mmHg
Molecular Formula	C₁₈H₁₄KNO₃
Molecular Weight	331.40700
Flash Point	236.2ºC
Exact Mass	331.06100
PSA	66.16000
LogP	2.69110
Vapour Pressure	1.6E-09mmHg at 25°C