174064-08-5
174064-08-5 structure
- Name: Oxaprozin, potassium salt
- Chemical Name: potassium,3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoate
- CAS Number: 174064-08-5
- Molecular Formula: C18H14KNO3
- Molecular Weight: 331.40700
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2016-06-12 15:36:17
- Modify Date: 2024-01-22 06:40:05
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Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2].
| Name | potassium,3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoate |
|---|---|
| Synonyms |
oxaprozin potassium salt
potassium 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoate Daypro Alta ML56O2Z92I UNII-ML56O2Z92I 2-Oxazolepropanoic acid,4,5-diphenyl-,potassium salt OXAPROZIN POTASSIUM 4,5-diphenyl-2-oxazolepropionic acid potassium salt |
| Description | Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2]. |
|---|---|
| Related Catalog | |
| Target |
COX-1:2.2 μM (IC50) COX-2:36 μM (IC50) NF-κB Akt pAKT IKK |
| In Vitro | Oxaprozin (0-100 μM) induces apoptosis in a dose-dependent manner. Oxaprozin increases caspase-3 activity in the activated but not in the resting condition. NF-κB activation is inhibited by Oxaprozin (50 μM). Oxaprozin inhibits activation of the IKK system induced by the reagent IκBα[1]. Oxaprozin (100 μM) induces the strongest proapoptotic effect and significantly increases CD40L-treated monocyte apoptosis. Oxaprozin treatment inhibits CD40L-induced Akt and NF-κB (p65) phosphorylation[2]. |
| References |
| Boiling Point | 467ºC at 760mmHg |
|---|---|
| Molecular Formula | C18H14KNO3 |
| Molecular Weight | 331.40700 |
| Flash Point | 236.2ºC |
| Exact Mass | 331.06100 |
| PSA | 66.16000 |
| LogP | 2.69110 |
| Vapour Pressure | 1.6E-09mmHg at 25°C |