CP-060

Modify Date: 2024-01-07 18:20:05

Use of CP-060

CP-060 is a potent Ca2+ antagonist, inhibits Ca2+ overload and possesses antioxidant and cardioprotective activities.

Name	CP-060

Description	CP-060 is a potent Ca2+ antagonist, inhibits Ca2+ overload and possesses antioxidant and cardioprotective activities.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
In Vitro	CP-060 (0.5, 5 μM) inhibits rabbit LDL oxidation induced by soybean lipoxygenase by 12.9% and 3.0%, respectively[1].
In Vivo	CP-060 (100 mg/kg, i.v.) increases the coronary blood flow by 96% in anesthetized dogs[2].
References	[1]. Kato T, et al. Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 1. 2-(3, 5-di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl)thiazolidinones. J Med Chem. 1998 Oct 22;41(22):4309-16. [2]. Kato T, et al. Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 2. Structure-activity relationships of thiazolidinone derivatives. J Med Chem. 1999 Aug 12;42(16):3134-46.

Molecular Formula	C₃₀H₄₂N₂O₅S
Molecular Weight	542.73

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Price: $1536/1mg

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